District cancer indicators grow among youthful people – can changes in intestinal bacteria to explain why?

Disturbing trends show that colorectal or intestine cancer growing in younger people. If the growth persists, it is expected that colorectal cancer will become the main cause of cancer -related deaths among youthful adults around the world until 2030.

Until recently, The reasons for this growth They were largely unclear or unknown. Now Research indicates Surprising suspect: intestinal bacteria.

The last study reveals that exposure to childhood or maturation to toxins produced by some strains And colawhose growth is encouraged by a highly processed diet, it can put the foundations for aggressive intestinal cancers. This discovery can aid explain why people under 50 The fastest growing cancer epidemics our time.

Colorectal cancer is now The second biggest cause Death of cancer, but only one in three cases is diagnosed in the earliest stages. Often without symptoms In early forms, colorectal cancer usually begins as polyps and can take ten to 15 years. This snail-paced progress makes a regular screening test, especially because many patients do not experience any warning signs.

In the case of up-to-date research, the international team analyzed full DNA sequences of 981 colorectal cancer tumors from patients in 11 countries. They discovered striking geographical patterns in mutations leading to cancer.

Two specific mutation signatures – SBS88 and ID18 – distinguished colibactinDNA damaging toxin produced by some And cola strains. These bacterial “fingerprints” were 3.3 times more often in patients diagnosed 40 years ago than in patients over 70 years elderly. These mutations appear early in the development of cancer, which suggests that the damage may occur – even decades – before diagnosing cancer.

Read more: Why regular yogurt eating can reduce the risk of bowel cancer

Intestinal microbiome

Kolibactin does not cause random DNA damage. The study showed that it tends to aim APC geneAn essential tumor suppressor that normally controls cell growth.

In positive calibactin cancers, about 25% of APC mutations had a unique toxin signature. This direct blow to the internal “braking system” of the body can explain why these cancers appear earlier in life.

Molecular analysis has shown that colibactin mutations often appear during the first ten years of life. Although it suggests toxin, it can quietly colonize the guts of children and Initiate cancer changes Early it should be noted that it remains theory; The study did not directly examine children or youthful adults.

Despite this, the tests are mapping the micro -formal risk pattern of cancer. These intestinal bacteria are not the same as those that cause food poisoning – they often live in us and make favorable roles.

But their composition may vary significantly depending on the region. Countries, including Argentina, Brazil and Russia-on where the colorectal cancer indicators are climbing-the higher level of mutations associated with columbactin appeared.

This may reflect regional differences in Intestinal microbiome Under the influence of diet (especially ultra -free food), the exploit of antibiotics and environmental factors. On the other hand, Japan and South Korea, where the rates are historically high, but stable, showed various mutation patterns, which suggests that other causes can dominate.

Perhaps the most provocative discovery concerns when it will occur bacterial damage. Unlike the risk associated with the lifestyle that increases for decades, kiibactin seems to hit during a narrow window – when the microbiome is still formed in childhood or early adulthood.

Potential triggers may include the repetitive exploit of antibiotics, which disturb vigorous intestinal bacteria, highly processed diets that favor E. coli Growth and life in a city that reduces exposure to various microbial environments.

Not only genes and lifestyle

These discoveries may also indicate up-to-date prevention strategies. Screening programs can focus on younger adults carrying these high -risk bacterial strains, using faeces to detect colibactin genes.

Diets prosperous in fiber and low in processed foods can promote A healthier intestinal microbiomepotentially suppressing harmful bacteria. Research also add weight to lowering the ages of colorectal cancer around the world, because many cases of early beginning will not detect in accordance with the current guidelines.

Although this test is the main step forward, there are many questions. Why do some people wear bacteria that produce calibactin, but never develop cancer? How do newfangled lifestyle factors strengthen – or soothe – these risk of microorganisms? We know that cancer results from the elaborate the interaction between Our genes and our environment – including a microscopic world in us.

Since scientists still combine dots, one thing is clear: the epidemic of colorectal cancer of the 21st century could begin with the still battle of microorganisms in our intestines, a decades before the diagnosis. This emerging view of cancer not only as a genetic disease or lifestyle, but also as a microorganism – can basically transform the way of thinking about preventing future generations.